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Characteristic API Advanced Intermediate Impurity

Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[7-[[(1S,2R)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

CAS No.：NA
Product No.：152-94
Configuration：绝对构型
From：工艺杂质
Ethanol, 2-[[(3aS,4R,6S,6aR)-6-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

CAS No.：NA
Product No.：152-72B
Configuration：绝对构型
From：工艺杂质
2-(((3aS,4R,6S,6aR)-6-(7-(((1S,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

CAS No.：NA
Product No.：152-72E
Configuration：绝对构型
From：工艺杂质
2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylsulfonyl)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

CAS No.：NA
Product No.：152-70F
Configuration：绝对构型
From：工艺杂质
4H-Cyclopenta-1,3-dioxol-4-ol, 6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-, (3aR,4S,6R,6aS)-

CAS No.：220241-60-1
Product No.：152-99
Configuration：绝对构型
From：工艺杂质
Ethanol, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

CAS No.：376608-65-0
Product No.：152-47
Configuration：绝对构型
From：工艺杂质
5-Pyrimidinamine, 4,6-dichloro-2-(propylthio)-

CAS No.：145783-15-9
Product No.：152-34
Configuration：绝对构型
From：工艺杂质
Ethanol, 2-[[(3aS,4R,6S,6aR)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

CAS No.：NA
Product No.：152-640
Configuration：绝对构型
From：工艺杂质
ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate (2R,3R)-2,3-dihydroxysuccinate

CAS No.：NA
Product No.：152-629
Configuration：绝对构型
From：工艺杂质
Carbamic acid, (tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)-, phenylmethyl ester, (3aα,4α,6α,6aα)- (9CI)

CAS No.：88756-84-7
Product No.：152-307
Configuration：绝对构型
From：工艺杂质
Carbamic acid, N-[(3aS,4R,6S,6aR)-tetrahydro-6-(2-hydroxyethoxy)-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-, phenylmethyl ester

CAS No.：274693-54-8
Product No.：152-43
Configuration：绝对构型
From：工艺杂质
Acetic acid, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

CAS No.：1402150-27-9
Product No.：152-42C
Configuration：绝对构型
From：工艺杂质

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Characteristic API Advanced Intermediate Impurity

Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[7-[[(1S,2R)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

Ethanol, 2-[[(3aS,4R,6S,6aR)-6-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

2-(((3aS,4R,6S,6aR)-6-(7-(((1S,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylsulfonyl)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

4H-Cyclopenta-1,3-dioxol-4-ol, 6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-, (3aR,4S,6R,6aS)-

Ethanol, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

5-Pyrimidinamine, 4,6-dichloro-2-(propylthio)-

Ethanol, 2-[[(3aS,4R,6S,6aR)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate (2R,3R)-2,3-dihydroxysuccinate

Carbamic acid, (tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)-, phenylmethyl ester, (3aα,4α,6α,6aα)- (9CI)

Carbamic acid, N-[(3aS,4R,6S,6aR)-tetrahydro-6-(2-hydroxyethoxy)-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-, phenylmethyl ester

Acetic acid, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

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Characteristic APIAdvanced IntermediateImpurity

2-(((3aS,4R,6S,6aR)-6-(7-(((1S,2R)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylsulfonyl)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol

4H-​Cyclopenta-​1,​3-​dioxol-​4-​ol, 6-​[[5-​amino-​6-​chloro-​2-​(propylthio)​-​4-​pyrimidinyl]​amino]​tetrahydro-​2,​2-​dimethyl-​, (3aR,​4S,​6R,​6aS)​-

Ethanol, 2-​[[(3aR,​4S,​6R,​6aS)​-​6-​aminotetrahydro-​2,​2-​dimethyl-​4H-​cyclopenta-​1,​3-​dioxol-​4-​yl]​oxy]​-​, (2R,​3R)​-​2,​3-​dihydroxybutanedioat​e (1:1)

5-​Pyrimidinamine, 4,​6-​dichloro-​2-​(propylthio)​-

Ethanol, 2-​[[(3aS,​4R,​6S,​6aR)​-​6-​[[5-​amino-​6-​chloro-​2-​(propylthio)​-​4-​pyrimidinyl]​amino]​tetrahydro-​2,​2-​dimethyl-​4H-​cyclopenta-​1,​3-​dioxol-​4-​yl]​oxy]​-

ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate (2R,3R)-2,3-dihydroxysuccinate

Carbamic acid, (tetrahydro-​6-​hydroxy-​2,​2-​dimethyl-​4H-​cyclopenta-​1,​3-​dioxol-​4-​yl)​-​, phenylmethyl ester, (3aα,​4α,​6α,​6aα)​- (9CI)

Carbamic acid, N-​[(3aS,​4R,​6S,​6aR)​-​tetrahydro-​6-​(2-​hydroxyethoxy)​-​2,​2-​dimethyl-​4H-​cyclopenta-​1,​3-​dioxol-​4-​yl]​-​, phenylmethyl ester

Acetic acid, 2-​[[(3aR,​4S,​6R,​6aS)​-​6-​aminotetrahydro-​2,​2-​dimethyl-​4H-​cyclopenta-​1,​3-​dioxol-​4-​yl]​oxy]​-

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Characteristic API Advanced Intermediate Impurity

4H-Cyclopenta-1,3-dioxol-4-ol, 6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-, (3aR,4S,6R,6aS)-

Ethanol, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

5-Pyrimidinamine, 4,6-dichloro-2-(propylthio)-

Ethanol, 2-[[(3aS,4R,6S,6aR)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

Carbamic acid, (tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)-, phenylmethyl ester, (3aα,4α,6α,6aα)- (9CI)

Carbamic acid, N-[(3aS,4R,6S,6aR)-tetrahydro-6-(2-hydroxyethoxy)-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]-, phenylmethyl ester

Acetic acid, 2-[[(3aR,4S,6R,6aS)-6-aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-