Results
R&D and Innovation
Tianshu Pharmaceutical adheres to innovation-driven development, with differentiated technologies as its core, to accomplish the industrialized production of pharmaceuticals featuring high technical barriers and continuous multi-step complex processes.

Meanwhile, it actively explores more green, safe and intelligent advanced engineering technologies in the biopharmaceutical field, such as continuous flow, micro-packed bed, metal catalysis and bio-enzyme catalysis, so as to continuously provide customers with more efficient, high-quality and cost-effective products and services.

Chiral Drugs Synthesis and Analysis Technology

Stereoselective synthesis and analysis of multi-chiral center drugs, meet the quality control requirements for chiral impurities.

  • Chiral Drug Synthesis

    At the project initiation stage, we focus on the stereoselective synthesis and industrialization of APIs and intermediates with multi-chiral centers, which feature complex structures and high technical barriers.

  • Chiral Drug Analysis

    Equipped with complete hardware configurations (chiral HPLC, UPLC and GC), a rich variety of detection methods and a well-developed process control strategy, it ensures the analysis and research as well as quality control of chiral impurities.

Crystal Form & Salt Form Screening Technology

The technology platform has advanced crystal and salt form screening and development strategies, which can quickly and effectively solve technical problems such as difficult crystallization, poor physical and chemical properties, and complex polymorphism.

  • Salt Form Screening

    Evaluate the thermodynamic properties of advantageous drug salt forms and their crystal forms through comprehensive DSC & TGA analysis

  • Polymorph Screening

    Investigate the dehydration behavior of API under different heating temperatures via TGA

  • Salt Form/Polymorph Solid-State Research

    Quantify impurity crystal forms in API by DSC

  • Crystallization Process Development

    Evaluate the solid-state physical stability of API under different influencing factors using XRD

Biological Enzyme Engineering Technology

Developed based on molecular biotechnology, it is more environmentally friendly, features milder reactions and higher chiral stereoselectivity, effectively breaking through the limitations of traditional synthesis technologies.

  • Molecular Modification

    Utilize multiple methods such as gene libraries and 3D modeling for molecular design, alter enzyme gene sequences, and thereby modify protein structure and function.

  • Fermentation

    Achieve fermentation process optimization, strain preservation, protein production, and semi-synthetic metabolic extraction.

  • Enzyme Catalysis

    Targeted substitution of traditional chemical synthesis methods, providing mild and highly selective technical conditions, obtaining high quality pure products, and breaking through the limitations of synthesis.

Molecular Biotechnology Chemical Products
Continuous Flow Engineering Technology

Homogeneous and heterogeneous continuous Flow & micro-packed bed technologies, these technologies reduce the risk of high-risk reactions, making pharmaceutical production more precise, safer, and more efficient.

  1. Continuous Flow Engineering Technology
  2. Supported Catalyst Development
  3. Micro-Packed Bed Catalytic Hydrogenation

  • High mass and heat transfer efficiency, enabling faster reactions

    Precise process control with no scale-up effect

    Less on-line material, ensuring safer reactions

    Capable of withstanding harsh reaction conditions, reducing the risk of high-risk reactions.

  • Spherical supports with uniform size and high strength

    Wide range of metal catalysts such as Pd, Pt, Ru, Ni, etc. with high activity, strong selectivity and high stability

  • High-efficiency catalysis, safe and controllable

    Significantly reducing catalyst costs with high productivity

    High degree of automation and easy operation

Photochemical Technology

"Using light as a reagent", it is energy-saving, green and environmentally friendly, easy to control, highly selective, and can be applied to a variety of reactions.

  1. Photochemical Parallel Reactor
  2. Photo-microfluidic Device
  3. Continuous Photoreaction Production Equipment

  • Equipped with multiple light source configurations for parameter screening of reaction conditions

  • Microflow/continuous photocatalysis, capable of conducting multiphase chemical reactions, with rapid mixing and heat exchange

  • Continuous photocatalysis with cascade scale-up