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Characteristic API Advanced Intermediate Impurity

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

CAS No.：1564265-95-7
Product No.：65-10C
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

CAS No.：1564265-94-6
Product No.：65-10A
Configuration：绝对构型
From：工艺杂质
(S)-2-((tert-butoxycarbonyl)amino)-2-((1s,3R,5S,7R)-4-oxoadamantan-1-yl)acetic acid

CAS No.：NA
Product No.：65-90
Configuration：绝对构型
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3,5-dihydroxy-, (αS)-

CAS No.：681282-72-4
Product No.：65-80
Configuration：绝对构型
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, 3-hydroxy-α-oxo-

CAS No.：709031-28-7
Product No.：65-44
Configuration：无
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, methyl ester, (αS)-

CAS No.：1234196-30-5
Product No.：65-22
Configuration：绝对构型
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (αS)-

CAS No.：1234196-29-2
Product No.：65-21
Configuration：绝对构型
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, (αR)-

CAS No.：1334321-39-9
Product No.：65-7M
Configuration：绝对构型
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-

CAS No.：361441-97-6
Product No.：65-6
Configuration：绝对构型
Generic Name：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetic acid, α-amino-, hydrochloride (1:1), (αS)-

CAS No.：102502-64-7
Product No.：65-5
Configuration：绝对构型
From：工艺杂质
Tricyclo[3.3.1.13,7]decane-1-acetamide, 3-hydroxy-α-[[(1R)-2-hydroxy-1-phenylethyl]amino]-, (αS)-

CAS No.：1656249-10-3
Product No.：65-4B
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1R,3S,5R)-, methanesulfonate (1:1)

CAS No.：1564266-70-1
Product No.：66-12B
Configuration：绝对构型
From：工艺杂质

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Characteristic API Advanced Intermediate Impurity

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

(S)-2-((tert-butoxycarbonyl)amino)-2-((1s,3R,5S,7R)-4-oxoadamantan-1-yl)acetic acid

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3,5-dihydroxy-, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, 3-hydroxy-α-oxo-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, methyl ester, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, (αR)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-amino-, hydrochloride (1:1), (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetamide, 3-hydroxy-α-[[(1R)-2-hydroxy-1-phenylethyl]amino]-, (αS)-

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1R,3S,5R)-, methanesulfonate (1:1)

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Characteristic APIAdvanced IntermediateImpurity

2-​Azabicyclo[3.1.0]​hexane-​3-​carbonitrile, 2-​[(2R)​-​2-​amino-​2-​(3-​hydroxytricyclo[3.3.​1.13,​7]​dec-​1-​yl)​acetyl]​-​, (1R,​3R,​5R)​-

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

(S)-2-((tert-butoxycarbonyl)amino)-2-((1s,3R,5S,7R)-4-oxoadamantan-1-yl)acetic acid

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, α-​[[(1,​1-​dimethylethoxy)​carbonyl]​amino]​-​3,​5-​dihydroxy-​, (αS)​-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, 3-​hydroxy-​α-​oxo-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, α-​[[(1,​1-​dimethylethoxy)​carbonyl]​amino]​-​3-​hydroxy-​, methyl ester, (αS)​-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, α-​[[(1,​1-​dimethylethoxy)​carbonyl]​amino]​-​, methyl ester, (αS)​-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, α-​[[(1,​1-​dimethylethoxy)​carbonyl]​amino]​-​3-​hydroxy-​, (αR)​-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, α-​[[(1,​1-​dimethylethoxy)​carbonyl]​amino]​-​, (αS)​-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetic acid, α-​amino-​, hydrochloride (1:1)​, (αS)​-

Tricyclo[3.3.1.1<sup>3,​7</sup>]​decane-​1-​acetamide, 3-​hydroxy-​α-​[[(1R)​-​2-​hydroxy-​1-​phenylethyl]​amino]​-​, (αS)​-

2-​Azabicyclo[3.1.0]​hexane-​3-​carboxamide, (1R,​3S,​5R)​-​, methanesulfonate (1:1)

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Characteristic API Advanced Intermediate Impurity

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3,5-dihydroxy-, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, 3-hydroxy-α-oxo-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, methyl ester, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxy-, (αR)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetic acid, α-amino-, hydrochloride (1:1), (αS)-

Tricyclo[3.3.1.1<sup>3,7</sup>]decane-1-acetamide, 3-hydroxy-α-[[(1R)-2-hydroxy-1-phenylethyl]amino]-, (αS)-

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1R,3S,5R)-, methanesulfonate (1:1)