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Characteristic API Advanced Intermediate Impurity

Benzenemethanol, α-(chloromethyl)-3,4-difluoro-, (αS)-

CAS No.：1006376-60-8
Product No.：152-12
Configuration：绝对构型
From：工艺杂质
Ethanone, 2-chloro-1-(3,4-difluorophenyl)-

CAS No.：51336-95-9
Product No.：152-11
Configuration：无
From：工艺杂质
Cyclopropanamine, 2-(3,4-difluorophenyl)-, hydrochloride (1:1), (1S,2S)-

CAS No.：NA
Product No.：152-19Z
Configuration：消旋体
From：工艺杂质
(1S,2R)-2-(3,4-difluorophenyl)cyclopropan-1-amine (S)-2-hydroxy-2-phenylacetate

CAS No.：NA
Product No.：152-19E
Configuration：绝对构型
From：工艺杂质
(1S,3S,5S)-N-methyl-2-azabicyclo[3.1.0]hexane-3-carboxamide oxalate

CAS No.：NA
Product No.：66-8D
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-2-carboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (1S,3S,5S)-

CAS No.：361440-67-7
Product No.：66-7
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3R,5S)-, methanesulfonate (1:1)

CAS No.：1564266-74-5
Product No.：66-12D
Configuration：绝对构型
From：工艺杂质
1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-5-oxo-, 1,1-dimethylethyl ester, (2S)-

CAS No.：1448789-90-9
Product No.：66-33
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-methyl ester, (1S,3S,5S)-

CAS No.：1109791-02-7
Product No.：66-32
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, (1S,3S,5S)-, 2,2,2-trifluoroacetate (1:1)

CAS No.：1523541-80-1
Product No.：66-31
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, (1S,3S,5S)-, ethyl ester, 2,2,2-trifluoroacetate (1:1)

CAS No.：361440-58-6
Product No.：66-30
Configuration：绝对构型
From：工艺杂质
2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) ester, (1S,3S,5S)-

CAS No.：197142-36-2
Product No.：66-10
Configuration：绝对构型
From：工艺杂质

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Characteristic API Advanced Intermediate Impurity

Benzenemethanol, α-(chloromethyl)-3,4-difluoro-, (αS)-

Ethanone, 2-chloro-1-(3,4-difluorophenyl)-

Cyclopropanamine, 2-(3,4-difluorophenyl)-, hydrochloride (1:1), (1S,2S)-

(1S,2R)-2-(3,4-difluorophenyl)cyclopropan-1-amine (S)-2-hydroxy-2-phenylacetate

(1S,3S,5S)-N-methyl-2-azabicyclo[3.1.0]hexane-3-carboxamide oxalate

2-Azabicyclo[3.1.0]hexane-2-carboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (1S,3S,5S)-

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3R,5S)-, methanesulfonate (1:1)

1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-5-oxo-, 1,1-dimethylethyl ester, (2S)-

2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-methyl ester, (1S,3S,5S)-

2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, (1S,3S,5S)-, 2,2,2-trifluoroacetate (1:1)

2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, (1S,3S,5S)-, ethyl ester, 2,2,2-trifluoroacetate (1:1)

2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) ester, (1S,3S,5S)-

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Characteristic APIAdvanced IntermediateImpurity

Benzenemethanol, α-​(chloromethyl)​-​3,​4-​difluoro-​, (αS)​-

Ethanone, 2-​chloro-​1-​(3,​4-​difluorophenyl)​-

Cyclopropanamine, 2-​(3,​4-​difluorophenyl)​-​, hydrochloride (1:1)​, (1S,​2S)​-

(1S,2R)-2-(3,4-difluorophenyl)cyclopropan-1-amine (S)-2-hydroxy-2-phenylacetate

(1S,3S,5S)-N-methyl-2-azabicyclo[3.1.0]hexane-3-carboxamide oxalate

2-​Azabicyclo[3.1.0]​hexane-​2-​carboxylic acid, 3-​(aminocarbonyl)​-​, 1,​1-​dimethylethyl ester, (1S,​3S,​5S)​-

2-​Azabicyclo[3.1.0]​hexane-​3-​carboxamide, (1S,​3R,​5S)​-​, methanesulfonate (1:1)

1-​Pyrrolidinecarboxyli​c acid, 2-​(aminocarbonyl)​-​5-​oxo-​, 1,​1-​dimethylethyl ester, (2S)​-

2-​Azabicyclo[3.1.0]​hexane-​2,​3-​dicarboxylic acid, 2-​(1,​1-​dimethylethyl) 3-​methyl ester, (1S,​3S,​5S)​-

2-​Azabicyclo[3.1.0]​hexane-​3-​carboxylic acid, (1S,​3S,​5S)​-​, 2,​2,​2-​trifluoroacetate (1:1)

2-​Azabicyclo[3.1.0]​hexane-​3-​carboxylic acid, (1S,​3S,​5S)​-​, ethyl ester, 2,​2,​2-​trifluoroacetate (1:1)

2-​Azabicyclo[3.1.0]​hexane-​2,​3-​dicarboxylic acid, 2-​(1,​1-​dimethylethyl) ester, (1S,​3S,​5S)​-

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Characteristic API Advanced Intermediate Impurity

Benzenemethanol, α-(chloromethyl)-3,4-difluoro-, (αS)-

Ethanone, 2-chloro-1-(3,4-difluorophenyl)-

Cyclopropanamine, 2-(3,4-difluorophenyl)-, hydrochloride (1:1), (1S,2S)-

2-Azabicyclo[3.1.0]hexane-2-carboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (1S,3S,5S)-

2-Azabicyclo[3.1.0]hexane-3-carboxamide, (1S,3R,5S)-, methanesulfonate (1:1)

1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-5-oxo-, 1,1-dimethylethyl ester, (2S)-

2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) 3-methyl ester, (1S,3S,5S)-

2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, (1S,3S,5S)-, 2,2,2-trifluoroacetate (1:1)

2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, (1S,3S,5S)-, ethyl ester, 2,2,2-trifluoroacetate (1:1)

2-Azabicyclo[3.1.0]hexane-2,3-dicarboxylic acid, 2-(1,1-dimethylethyl) ester, (1S,3S,5S)-